Inflammatory epilepsy?
Posted on : 20-06-2011 | By : Fabio Sanchez | In : Research
Tags: epilepsy, inflammation
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Could inflammation cause epilepsy? Many researches think that is the case. This is a new and exciting field of research that might bring about new ways to manage this terrible disease.Here is one paper that suggests TNF alpha, an immune molecule with proinflammatory properties, can affect the way nerve cells respond to their environments.
Kiarash Riazi, Michael A. Galic, J. Brent Kuzmiski, Winnie Ho, Keith A. Sharkey, and Quentin J. Pittman
Proc Natl Acad Sci U S A. 2008 November 4; 105(44): 17151–17156. PMC:2579393
Another interesting paper that was published the same year explores the idea that controlling inflammation has a positive impact on epilepsy.
Nicola Marchi, Qingyuan Fan, Chaitali Ghosh, Vincent Fazio, Francesca Bertolini, Giulia Betto, Ayush Batra, Erin Carlton, Imad Najm, Tiziana Granata, and Damir Janigro
Neurobiol Dis. Author manuscript; available in PMC 2011 February 28.
Neurobiol Dis. 2009 February; 33(2): 171–181.
PMCID:PMC3045783
Now, in the May 2011 issue of the journal Epilepsia, appeared a series of papers discussing this topic in depth. Here are the links to their summaries.
Immuno- and antiinflammatory therapies in epileptic disorders.
Özkara Ç, Vigevano F.
Epilepsia. 2011 May;52 Suppl 3:45-51. Review.
- PMID:21542846
Molecular cascades that mediate the influence of inflammation on epilepsy.
Friedman A, Dingledine R.
Epilepsia. 2011 May;52 Suppl 3:33-9. Review.
- PMID:21542844
Inflammation in epilepsy: clinical observations.
Aronica E, Crino PB.
Epilepsia. 2011 May;52 Suppl 3:26-32. Review.
- PMID:21542843
Granata T, Cross H, Theodore W, Avanzini G.
Epilepsia. 2011 May;52 Suppl 3:5-11. Review.
- PMID:21542839
Vezzani A, Rüegg S.
Epilepsia. 2011 May;52 Suppl 3:1-4. doi: 10.1111/j.1528-1167.2011.03028.x. No abstract available.
- PMID:21542838